Acrylic acids and derivatives
Apexbio Technology LLC KW-2478 819812-04-9 100mg
KW-2478 (CAS 819812-04-9) is a potent non-ansamycin inhibitor of heat shock protein 90 (Hsp90) Unlike traditional Hsp90 inhibitors such as 17-AAG KW-2478 exhibits improved aqueous solubility and reduced hepatotoxicity In multiple myeloma cell models KW-2478 induces degradation of Hsp90 client proteins and leads to downregulation of IgH translocation products including FGFR3 c-Maf and cyclin D1 thereby inhibiting cell proliferation and promoting apoptosis Additionally KW-2478 reduces levels of Cdk9 and phosphorylated 4E-BP1 further suppressing oncogenic transcriptional regulators This compound is a valuable tool for studying Hsp90-mediated pathways and evaluating therapeutic strategies in hematological malignancies
Medchemexpress LLC HY-A0060 10mg Medchemexpress, Malotilate CAS:59937-28-9 Purity:>98%
Medchemexpress, HY-A0060 10mg Malotilate CAS:59937-28-9 Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC Trimipramine (maleate),5g CAS# 521-78-8
Trimipramine (maleate) is a potent antagonist of histamine H1 receptor, serotonin 5-HT2A, and α1-adrenergic receptors [1].The histamine H1 receptor is widely expressed tissues, such as smooth muscles, vascular endothelial cells, heart, and the central nervous system. Histamine H1 receptor (H1R) antagonists are very effective drugs alleviating the symptoms of allergic reactions [2]. 5-HT2A receptor shows constitutive activity. Variations in5-HT2A receptor can produce profound alterations in cognitive states [3]. Other sizes are also available. Please inqury us for quote.
Medchemexpress LLC Escin IA (standard) | 123748-68-5 | 1131.26 g/mol | C55H86O24 | 10 MG
Escin IA is a triterpene saponin isolated from Aesculus hippocastanum and provided as an analytical standard for research applications. It inhibits HIV-1 protease (IC50 ≈ 35 μM) and has demonstrated anti-metastatic activity in triple-negative breast cancer models by inhibiting epithelial-mesenchymal transition and down-regulating LOXL2 expression.
- Triterpene saponin natural product
- Inhibits HIV-1 protease (IC50 ~35 μM)
- Exhibits anti-TNBC metastasis activity via EMT inhibition
- Intended for research and analytical applications
- Available as a solid, common pack size 10 MG
- Molecular weight 1131.26 g/mol; CAS 123748-68-5
Sigma Aldrich Fine Chemicals Biosciences Bisoprolol hemifumarate salt >=98% (HPLC), solid | 104344-23-2 | MFCD00792743 | 50MG
Bisoprolol hemifumarate salt >=98% (HPLC), solid | Purity: >=98% (HPLC) | Mol Wt: 383.48 | 104344-23-2 | MFCD00792743 | 50MG
Medchemexpress LLC HY-103310 10mg Medchemexpress, MRS1845 CAS:544478-19-5 Purity:>98%
Medchemexpress, HY-103310 10mg MRS1845 CAS:544478-19-5 MRS1845 is a selective store-operated calcium (SOC) channel inhibitor with an IC50 of 1.7 μM. MRS1845 is an ORAI1 inhibitor. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-13727A 5mg Medchemexpress, Pixantrone (dimaleate) CAS:144675-97-8 Purity:>98%
Medchemexpress, HY-13727A 5mg Pixantrone (dimaleate) CAS:144675-97-8 Pixantrone dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.